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The Supported Studies Programme
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Consumer Health



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The below areas are of particular interest to the review committee. This was last updated in May 2019.

[Oral Health]
New plaque-reducing or plaque-inhibiting solutions

The build-up of dental plaque is the precursor for several oral diseases, including gum disease. In the early stages, this can lead to soreness, inflammation and bleeding of the gums on brushing. Therefore, we are seeking to develop products that help reverse the early signs of gum disease and prevent it from recurring.
To achieve this, we are seeking opportunities that reduce or inhibit the attachment of plaque to oral surfaces or that break up existing plaque without the need for antimicrobials. Ideally, these ingredients can be incorporated into a mouthwash or toothpaste, but other formats would also be considered.

Gum health

Sodium bicarbonate is an ingredient in various toothpastes to help tackle early-stage gum disease (gingivitis) and maintain healthy gums. However, when present in high concentrations, sodium bicarbonate gives the toothpaste a very strong, salty taste which results in low acceptability by consumers. We are seeking solutions to mask the salty taste in toothpastes with high concentrations of sodium bicarbonate, so that this acceptance barrier is overcome and consumers can benefit from these products.

Enamel health

Teeth are subject to numerous challenges throughout the day from dietary sugars, acids and bacteria. Despite the use of fluoridated toothpaste and mouthwash, all of these factors have contributed to a significant rise in the number of fillings, enamel wear and sensitivity. Therefore, we are seeking solutions that would protect tooth enamel from these challenges and/or repair the damage that has been caused.

Denture cleansers

Denture cleansers are used to clean dentures when they are out of the mouth. They kill microorganisms and remove stains. Microorganisms can cause bad breath and denture-related infections. Denture cleansers may be used with brushing and they must not damage the denture.
The vast majority of denture cleansers are tablet formats based on bleaching technologies. A limited number of denture-cleaning pastes, liquids and powders exist.
Maintaining clean dentures, free from stains and bacteria, takes several steps in the bathroom routine and can be perceived as onerous by the consumer. A great improvement for consumer experience would be to have a highly efficient cleanser that would make denture care easier.
We are seeking solutions for alternative cleanser technologies that are more consumer-friendly but still meet or exceed the performance and safety of commercially available denture cleanser tablets

Denture adhesive

There are many commercially available denture adhesives based on pastes, powders or adhesive pads that may be placed on dentures to help them stay in place. The different products are based on different technologies; however, all share a common downside: an unpleasant sensorial experience and discomfort to the consumers. This unpleasant sensorial experience during use can be a result of:
• Chemical taste
• Overflow of the product from the edges of the denture
• Phase separation of the formulation, leading to a grainy or gritty texture
• Oil/greasy products leaving an oily sensation in the mouth
• The hard-to-remove product residue left behind in the mouth when the denture is taken out

[Pain Relief]
GSK scientists research and develop new self-treatment options targeting mild to moderate pain associated to multiple indications. The goal of GSK 's research in pain is to provide treatments and interventions that significantly improve the lives of patients living with a range of painful conditions.

[Respiratory]
• Upper respiratory tract infections
• Allergic and non-allergic rhinitis
• Tobacco addiction & smoking cessation/reduction
• Air pollution

[Skin health]
From birth through to old age, skin changes and adapts and is subject to numerous challenges. As such it requires the right maintenance to keep it healthy. Therefore, we are looking for technologies at different life stages. And technologies that work naturally with skin to repair the barrier and makes skin less sensitive.

Lip Health Solutions

A cold sore outbreak causes small blisters or sores on or around the lips. With treatment cold sores typically heal within 2-3 weeks, but the herpes virus remains. This virus can then reactivate causing a reoccurrence of the sore. For the consumer this can impact overall wellbeing and confidence. As such, we would like to identify: • Faster, better solutions for cold sore management before, during and after the cold sore episode
• Novel ways to mask the cold sore completely
• Ways to enable consumers to treat the cold sore to prevent the blister phase
• Clinically proven post-phase 2 technologies seeking partners for further development
• And Develop solutions for application compliance of the treatment and enable better delivery of the active. This could be novel dispensing and application solutions (e.g. Packaging) and solutions that increase cues for compliance and dosing application

Anti-Fungal Technologies

There are many commercially available nail lacquers, creams and topical solutions that offer onychomycosis (nail fungus) treatments. The different products are based on different technologies; however, they all share a common downside: a prolonged and lengthy application regimen (often up to a year). This generally results in a poor overall resolution of the fungal infection. Therefore, we are seeking anti-fungal treatment technologies that deliver faster, quicker better solutions for nail fungal infections. These solutions would be expected to deliver a step change versus the current market solutions across a number of areas (for example- consumer experience, active delivery and time to cure). Delivery mechanisms can be novel formats, actives and novel delivery systems and devices.

Anti-Itch Technologies

Itchy, irritated skin is a significant issue that can impact consumer wellbeing and quality of life. It can be a hallmark of atopic dermatitis, skin allergy-but also skin irritation from the number of exogenous factors such as the environment, insect bites and other triggering factors. Overall, resulting in inflamed skin. As such we are seeking topical or systemic therapeutic solutions to help relieve itch, allergy and skin inflammation (Eczema-prone, red, dry, itchy and flaky skin). Essentially, helping and supporting the management of a skin inflammation response. Delivery mechanisms such as novel formats (patches), actives and devices would be of interest.

Although GSK are more likely to support studies aligned to our current areas of interest for supported studies, we are interested in supporting studies that are innovative and contribute to scientific knowledge relating to a product, a medical condition or advancing a technology.



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